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GNF-PF-3777

GNF-PF-3777

Item no.	HY-100687-25mg
Manufacturer	MedChem Express
CASRN	77603-42-0
Amount	25 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 500 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.03
Citations	[1]Li J, et al. Establishment of a human indoleamine 2, 3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors. Eur J Med Chem. 2016 Nov 10;123:171-9.\|[2]Scovill J, et al. Antitrypanosomal activities of tryptanthrins. Antimicrob Agents Chemother. 2002 Mar;46(3):882-3.\|[3]Hwang JM, et al. Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents. J Nat Prod. 2013 Mar 22;76(3):354-67.
Smiles	O=C1N2C(C(C3=C2C=CC([N+]([O-])=O)=C3)=O)=NC4=CC=CC=C41
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	8-Nitrotryptanthrin
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Indoleamine 2, 3-Dioxygenase (IDO)
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	293.23
Product Description	GNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2, 3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM.
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO: 6.4 mg/mL (warming)
Manufacturer - Pathway	Metabolic Enzyme/Protease
Isoform	IDO2
Clinical information	No Development Reported

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HY-100687-25mg-safety-datasheet.pdf