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Laduviglusib (trihydrochloride)

Laduviglusib (trihydrochloride)

Item no.	HY-10182B-100mg
Manufacturer	MedChem Express
CASRN	1782235-14-6
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Specific against	other
Purity	99.11
Smiles	N#CC1=CC=C(NCCNC2=NC=C(C3=NC=C(C)N3)C(C4=CC=C(Cl)C=C4Cl)=N2)N=C1.[H]Cl.[H]Cl.[H]Cl
Alias	CHIR-99021 (trihydrochloride),CT99021 trihydrochloride
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Autophagy; GSK-3; Organoid; Wnt; β-catenin
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	574.72
Product Description	Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib trihydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib trihydrochloride induces autophagy[1][2][3].
Manufacturer - Research Area	Cancer
Solubility	DMSO : 250 mg/mL (ultrasonic)\|H2O : 19 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	Autophagy; PI3K/Akt/mTOR; Stem Cell/Wnt
Clinical information	No Development Reported
Isoform	GSK-3α; GSK-3β

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HY-10182B-100mg-safety-datasheet.pdf