LE 300

Item no.	HY-103428-1mg
Manufacturer	MedChem Express
CASRN	274694-98-3
Amount	1 mg
Quantity options	100 mg 10 mg 1 ea 1 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	98.5
Citations	[1]Kassack MU, et al. Pharmacological characterization of the benz[d]indolo[2,3-g]azecine LE300, a novel type of a nanomolar dopamine receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 2002 Dec;366(6):543-50. \|[2]Rostom SA. Novel fused pyrrole heterocyclic ring systems as structure analogs of LE 300: Synthesis and pharmacological evaluation as serotonin 5-HT(2A), dopamine and histamine H(1) receptor ligands. Arch Pharm (Weinheim). 2010 Feb;343(2):73-80.
Smiles	CN1CCC2=C(NC3=C2C=CC=C3)CC4=CC=CC=C4CC1
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	5-HT Receptor; Dopamine Receptor
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, protect from light, stored under nitrogen)
Molecular Weight	290.40
Product Description	LE 300 is a potent and selective dopamine D1-like receptor antagonist with Kis of 1.9 nM and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively. LE 300 is an antagonist of the 5-HT2A receptor with a pA2 of 8.32 in a rat tail artery assay[1][2].
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO: 29.04 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Isoform	5-HT2 Receptor; D1 Receptor; D5 Receptor; α-1 microglobulin
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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