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LY379268

LY379268

Item no.	HY-103558-1mg
Manufacturer	MedChem Express
CASRN	191471-52-0
Amount	1 mg
Quantity options	100 mg 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.84
Citations	[1]J A Monn, et al. Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors. J Med Chem. 1999 Mar 25;42(6):1027-40.\|[2]E F Sharpe, et al. Systemic pre-treatment with a group II mGlu agonist, LY379268, reduces hyperalgesia in vivo. Br J Pharmacol. 2002 Mar;135(5):1255-62.\|[3]Juan Turati, et al. Antioxidant and neuroprotective effects of mGlu3 receptor activation on astrocytes aged in vitro. Neurochem Int. 2020 Nov;140:104837.
Smiles	O=C([C@]1(N)CO[C@@]2([H])[C@H](C(O)=O)[C@@]12[H])O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Targets	mGluR
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	187.151
Product Description	LY379268 is a potent, selective and brain-penetrant mGlu2/3R agonist with EC50 values of 2.69 nM (mGlu2) and 4.48 nM (mGlu3). LY379268 has no activity on human mGlu 1a, 4a, 5a or 7a receptors. LY379268 has antioxidant and neuroprotective effects[1][2].
Manufacturer - Research Area	Neurological Disease
Solubility	0.1 M NaOH: 200 mg/mL (ultrasonic; adjust pH to 8 with NaOH)\|H2O: 2 mg/mL (ultrasonic; adjust pH to 10 with NaOH)
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Isoform	mGluR2; mGluR3
Clinical information	No Development Reported

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HY-103558-1mg-safety-datasheet.pdf