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GW3965 (hydrochloride)

GW3965 (hydrochloride)

Item no.	HY-10627A-1mg
Manufacturer	MedChem Express
CASRN	405911-17-3
Amount	1 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Neuroscience Metabolism Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Targets for Rodent Neurosciences Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.96
Citations	[1]Mitro, Nico., et al. LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals. Neurochemistry International (2012), 60(6), 616-621.\|[2]Guo, Deliang., et al. An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway. Cancer Discovery (2011), 1(5), 442-456.\|[3]Spyridon, Michael., et al. LXR as a novel antithrombotic target. Blood (2011), 117(21), 5751-5761.\|[4]Collins JL, et al. Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem. 2002 May 9;45(10):1963-6. bioRxiv. 2023 Mar 10.\|Environ Int. 2024 Nov 26:194:109168.\|Radboud University Nijmegen. 2021 Mar.\|Viruses. 2022, 14(3), 514.\|Am J Physiol Endocrinol Metab. 2019 Jun 1;316(6):E1136-E1145. \|Bioconjug Chem. 2015 Nov 18;26(11):2216-22. \|Biogerontology. 2025 Jan 31;26(2):49.\|Cancer Lett. 2023 May 5;216208.\|Cell Death Differ. 2020 Aug;27(8):2433-2450. \|J Am Heart Assoc. 2021 May 8;e018455.\|J Ethnopharmacol. 2023 May 24;315:116684.\|Sci Adv. 15 Jul 2022.\|Theranostics. 2020 Jul 11;10(19):8834-8850. \|Vet Microbiol. 2024 Jan, 288, 109948.
Smiles	ClC1=C(C(F)(F)F)C=CC=C1CN(CC(C2=CC=CC=C2)C3=CC=CC=C3)CCCOC4=CC(CC(O)=O)=CC=C4.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	LXR
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	618.51
Product Description	GW3965 hydrochloride is a potent and selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively[1][2][3].
Manufacturer - Research Area	Cardiovascular Disease; Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Clinical information	No Development Reported

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