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PF-06424439

PF-06424439

Item no.	HY-108341-5mg
Manufacturer	MedChem Express
CASRN	1469284-78-3
Amount	5 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 25 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.89
Citations	[1]Futatsugi K, et al. Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2). J Med Chem. 2015 Sep 24;58(18):7173-85.\|[2]Pabst B, et al. Mechanistic Characterization of Long Residence Time Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2). Biochemistry. 2018 Dec 26;57(51):6997-7010. bioRxiv. 2023 Jul 3.\|bioRxiv. 2025 Feb 19.\|Dev Comp Immunol. 2021 Jul 3;104197.\|Int J Biol Macromol. 2024 Nov 3:137235.\|Nat Commun. 2024 Sep 27;15(1):8273.\|Research Square Preprint. 2024 Feb 12.\|Theranostics. 2024 Jun 1;14(9):3470-3485.\|Int Immunopharmacol. 2024 Jun 24:138:112518.\|J Biol Chem. 2024 Mar 13:107168.\|J Dairy Sci. 2022 Feb 15;S0022-0302(22)00089-3.\|J Dairy Sci. 2024 Jun 6:S0022-0302(24)00897-X.\|J Virol. 2021 Nov 10;JVI0147321.\|Mol Metab. 2024 May 4:101953.
Smiles	O=C([C@H]1CN(C2=CC=C3C(NC(C4(N5N=CC(Cl)=C5)CC4)=N3)=N2)CCC1)N6CCCC6
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	Acyltransferase
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	439.94
Product Description	PF-06424439 is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM[1]. PF-06424439 is slowly reversible, time-dependent inhibitor, which inhibits DGAT2 in a noncompetitive mode with respect to the acyl-CoA substrate[2].
Manufacturer - Research Area	Metabolic Disease
Solubility	DMSO: 100 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Metabolic Enzyme/Protease
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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