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Alisertib

Alisertib

Item no.	HY-10971-1g
Manufacturer	MedChem Express
CASRN	1028486-01-2
Amount	1 g
Quantity options	100 mg 10 mM/1 mL 10 mg 1 g 1 mg 200 mg 25 mg 500 mg 50 mg 5 mg
Specific against	other
Purity	99.84
Smiles	O=C(C1=CC=C(C=C1OC)NC2=NC=C3CN=C(C4=CC(Cl)=CC=C4C3=N2)C5=C(C=CC=C5F)OC)O
Alias	MLN 8237
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Apoptosis; Aurora Kinase; Autophagy
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	518.92
Product Description	Alisertib (MLN 8237) is an orally active and selective Aurora A kinase inhibitor (IC50=1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib (MLN 8237) induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Antitumor activity[1][2][3].
Manufacturer - Research Area	Cancer
Solubility	DMSO : 25 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics
Clinical information	Phase 3
Isoform	Aurora A; Aurora B

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HY-10971-1g-safety-datasheet.pdf