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Dextran sulfate sodium salt (MW 4500-5500)

Dextran sulfate sodium salt (MW 4500-5500)

Item no.	HY-116282A-1g
Manufacturer	MedChem Express
CASRN	9011-18-1
Amount	1 g
Quantity options	100 mg 10 mMx1 mL 1 g 500 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Citations	[1]Johansson H, et al. Low molecular weight dextran sulfate: a strong candidate drug to block IBMIR in clinical islet transplantation. Am J Transplant. 2006 Feb;6(2):305-12. \|[2]Baba M, et al. Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6132-6.\|[3]Araki Y, et al. Dextran sulfate sodium administered orally is depolymerized in the stomach and induces cell cycle arrest plus apoptosis in the colon in early mouse colitis. Oncol Rep. 2012 Nov;28(5):1597-605. \|[4]Laumonier T,et al. Low molecular weight dextran sulfate binds to human myoblasts and improves their survival after transplantation in mice. Cell Transplant. 2013;22(7):1213-26.\|[5]Banz Y, et al. Dextran sulfate modulates MAP kinase signaling and reduces endothelial injury in a rat aortic clamping model. J Vasc Surg. 2009 Jul;50(1):161-70.
Smiles	[Dextran sulfate sodium salt (MW 4500-5500)]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	DSS (MW 4500-5500),DXS (MW 4500-5500)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Targets	Apoptosis; Complement System; HIV
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	4500-5500
Product Description	Dextran sulfate sodium salt (DSS) (MW 4500-5500) is a polymer of dehydrated glucose with a molecular weight of approximately 4500-5500. Dextran sulfate sodium salt with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 4500-5500) is an inhibitor of complement and coagulation pathways, and belongs to the glycosaminoglycans (GAG) family. Dextran sulfate sodium salt (MW 4500-5500) acts as an anticoagulant, antiviral, and anti-lipemic agent. Dextran sulfate sodium salt (MW 4500-5500) stops HIV-1 virus adsorption to host cells. Dextran sulfate sodium salt (MW 4500-5500) prevents NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 4500-5500) inhibits instant blood-mediated inflammatory reaction (IBMIR)[1][2][3][4][5].
Manufacturer - Research Area	Infection; Inflammation/Immunology
Solubility	H2O: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Apoptosis; Immunology/Inflammation
Clinical information	No Development Reported

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HY-116282A-1g-safety-datasheet.pdf