PIK-90

Item no.	HY-12030-1mg
Manufacturer	MedChem Express
CASRN	677338-12-4
Amount	1 mg
Quantity options	100 mg 10 mg 1 mg 50 mg 5 mg
Category	Oncology Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Bladder Cancer Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	99.70
Citations	[1]Knight ZA, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47.\|[2]Niedermeier M, et al. Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach. Blood. 2009 May 28;113(22):5549-57.\|[3]Cheng CK, et al. Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12722-7.
Smiles	O=C(NC1=NC2=C(C3=NCCN13)C=CC(OC)=C2OC)C4=CC=CN=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	DNA-PK; PI3K
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	351.36
Product Description	PIK-90 is a DNA-PK and PI3K inhibitor, which inhibits p110α, p110γ and DNA-PK with IC50s of 11, 18 and 13 nM, respectively.
Manufacturer - Research Area	Cancer
Solubility	DMSO : 6.67 mg/mL (ultrasonic; adjust pH to 2 with HCl)
Manufacturer - Pathway	Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Clinical information	No Development Reported
Isoform	PI3KC2α; PI3KC2β; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ; Vps34

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HY-12030-1mg-safety-datasheet.pdf