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m-PEG4-Br

m-PEG4-Br

Item no.	HY-130161-1g
Manufacturer	MedChem Express
CASRN	110429-45-3
Amount	1 g
Quantity options	100 mg 1 ea 1 g 250 mg 500 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	98.40
Citations	[1]Walker JA, et al. Hydrophilic Sequence-Defined Cross-Linkers for Antibody-Drug Conjugates.Bioconjug Chem. 2019 Nov 20;30(11):2982-2988.
Smiles	COCCOCCOCCOCCBr
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	ADC Related
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	ADC Linker; PROTAC Linkers
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	271.15
Product Description	m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab (HY-P9907). m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency[1]. m-PEG4-Br also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.
Manufacturer - Research Area	Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Antibody-drug Conjugate/ADC Related; PROTAC
Isoform	Cleavable Linker; PEG Linkers
Clinical information	No Development Reported

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HY-130161-1g-safety-datasheet.pdf