CC-401

Item no.	HY-13022A-1mg
Manufacturer	MedChem Express
CASRN	395104-30-0
Amount	1 mg
Quantity options	100 mg 10 mg 1 ea 1 mg 50 mg 5 mg
Category	Oncology Neuroscience Metabolism Diabetes Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer
Type	Inhibitors
Specific against	other
Purity	98.60
Citations	[1]Ma FY, et al. A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis. J Am Soc Nephrol. 2007 Feb;18(2):472-84.\|[2]Vasilevskaya IA, et al. Inhibition of JNK Sensitizes Hypoxic Colon Cancer Cells to DNA-Damaging Agents. Clin Cancer Res. 2015 Sep 15;21(18):4143-52.\|[3]Ma FY, et al. Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat. Lab Invest. 2009 Apr;89(4):470-84. Cell Syst. 2018 Apr 25;6(4):424-443.e7.\|J Med Chem. 2023 Mar 6.\|Mol Cancer Res. 2016 Aug;14(8):753-63.\|Harvard Medical School LINCS LIBRARY\|Int Immunopharmacol. 2024 Dec 9:145:113781.\|Science. 2017 Dec 1;358(6367):eaan4368.
Smiles	C1(C2=CC=CC(OCCN3CCCCC3)=C2)=NNC4=C1C=C(C=C4)C5=NC=NN5
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	JNK
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	388.47
Product Description	CC-401 is a potent inhibitor of all three forms of JNK with Ki of 25 to 50 nM.
Manufacturer - Research Area	Cancer
Solubility	DMSO: 39.7 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	MAPK/ERK Pathway
Isoform	JNK
Clinical information	Phase 2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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