DAPT

Item no.	HY-13027-200mg
Manufacturer	MedChem Express
CASRN	208255-80-5
Amount	200 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 200 mg 25 mg 50 mg 5 mg
Specific against	other
Purity	99.97
Smiles	FC1=CC(F)=CC(CC(N[C@H](C(N[C@H](C(OC(C)(C)C)=O)C2=CC=CC=C2)=O)C)=O)=C1
Alias	GSI-IX
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Amyloid-β; Apoptosis; Autophagy; Notch; Organoid; γ-secretase
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	432.46
Product Description	DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42, respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment[1][2].
Manufacturer - Research Area	Cancer; Inflammation/Immunology; Neurological Disease
Solubility	DMSO : 62.5 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Autophagy; Neuronal Signaling; Stem Cell/Wnt
Clinical information	No Development Reported

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HY-13027-200mg-safety-datasheet.pdf