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CX-5461

CX-5461

Item no.	HY-13323-200mg
Manufacturer	MedChem Express
CASRN	1138549-36-6
Amount	200 mg
Quantity options	100 mg 10 mg 1 mg 200 mg 25 mg 50 mg 5 mg
Specific against	other
Purity	99.49
Smiles	CC1=NC=C(CNC(C2=C3N(C4=NC(N5CCN(CCC5)C)=CC=C4C2=O)C6=C(S3)C=CC=C6)=O)N=C1
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	DNA/RNA Synthesis
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	513.61
Product Description	CX-5461 is a potent and oral rRNA synthesis inhibitor. It inhibits RNA polymerase I-driven transcription of rRNA with IC50s of 142, 113, and 54 nM in HCT-116, A375, and MIA PaCa-2 cells, respectively[1].
Manufacturer - Research Area	Cancer
Solubility	50 mM Sodium phosphate (pH 3.5) : 10 mg/mL (ultrasonic)\|DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : 55.56 mg/mL (ultrasonic; adjust pH to 2 with HCl)
Manufacturer - Pathway	Cell Cycle/DNA Damage
Clinical information	Phase 1

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