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Tofogliflozin (hydrate)

Tofogliflozin (hydrate)

Item no.	HY-13413-1g
Manufacturer	MedChem Express
CASRN	1201913-82-7
Amount	1 g
Quantity options	100 mg 10 mM/1 mL 10 mg 1 g 1 mg 25 mg 500 mg 50 mg 5 mg
Specific against	other
Purity	98.38
Smiles	O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@]21OCC3=C2C=C(CC4=CC=C(CC)C=C4)C=C3.O
Alias	CSG-452 hydrate
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	Reactive Oxygen Species (ROS); SGLT
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	404.45
Product Description	Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific sodium/glucose cotransporter 2 (SGLT2) inhibitor with an IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2[1]. Tofogliflozin partially inhibits high glucose-induced reactive oxyen species (ROS) generation in tubular cells[2].
Manufacturer - Research Area	Metabolic Disease
Solubility	DMSO : ≥ 100 mg/mL\|H2O : 0.33 mg/mL (ultrasonic)
Manufacturer - Pathway	Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB
Clinical information	Launched
Isoform	SGLT2

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