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TAK-733

TAK-733

Item no.	HY-13449-1mg
Manufacturer	MedChem Express
CASRN	1035555-63-5
Amount	1 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer Breast Cancer Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	99.79
Citations	[1]Dong Q, et al. Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1315-9.\|[2]Micel LN, et al. Antitumor activity of the MEK inhibitor TAK-733 against melanoma cell lines and patient-derived tumor explants. Mol Cancer Ther. 2015 Feb;14(2):317-25.
Smiles	O=C1C(C(NC2=CC=C(I)C=C2F)=C(F)C(N3C)=O)=C3N=CN1C[C@@H](O)CO
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	MEK
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	504.23
Product Description	TAK-733 is a potent and selective MEK allosteric site inhibitor with an IC50 of 3.2 nM.
Manufacturer - Research Area	Cancer
Solubility	DMSO: ≥ 33 mg/mL
Manufacturer - Pathway	MAPK/ERK Pathway
Isoform	MEK
Clinical information	Phase 1

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HY-13449-1mg-safety-datasheet.pdf