JSH-23

Item no.	HY-13982-1mg
Manufacturer	MedChem Express
CASRN	749886-87-1
Amount	1 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Brain Cancer Uterine, Ovarian & Cervical Cancer
Type	Inhibitors
Specific against	other
Purity	99.92
Citations	[1]Shin HM, et al. Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-kappaB without affecting IkappaB degradation. FEBS Lett. 2004 Jul 30;571(1-3):50-4.\|[2]Kumar A, et al. JSH-23 targets nuclear factor-kappa B and reverses various deficits in experimental diabetic neuropathy: effect on neuroinflammation and antioxidant defence. Diabetes Obes Metab. 2011 Aug;13(8):750-8.
Smiles	NC1=CC(C)=CC=C1NCCCC2=CC=CC=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	NF-κB
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	240.34
Product Description	JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC50 of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation[1].
Manufacturer - Research Area	Cancer; Metabolic Disease; Inflammation/Immunology
Solubility	DMSO: ≥ 56 mg/mL
Manufacturer - Pathway	NF-κB
Isoform	NF-κB
Clinical information	No Development Reported

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HY-13982-1mg-safety-datasheet.pdf