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Amiodarone (hydrochloride) (Standard)

Amiodarone (hydrochloride) (Standard)

Item no.	HY-14188R
Manufacturer	MedChem Express
CASRN	19774-82-4
Amount	1 ea
Quantity options	1 ea 100 mg 10 mg 25 mg 50 mg
Category	Reagents & Chemicals Other Chemicals
Type	Standard
Specific against	other
Citations	[1]Yihong Zhang,et al. Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking. Biochem Pharmacol. 2016 Aug 1;113:24-35. [2]Sabrina Le Bouter, et al. Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart. Circulation. 2004 Nov 9;110(19):3028-35. [3]Jie Weng, et al. Amiodarone induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts. Biomed Pharmacother. 2019 Jul;115:108889.
Smiles	CCCCC1=C(C(C2=CC(I)=C(OCCN(CC)CC)C(I)=C2)=O)C3=C(O1)C=CC=C3.Cl
ECLASS 10.1	42021590
ECLASS 11.0	42021590
UNSPSC	12352202
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference Standards
Manufacturer - Targets	Autophagy; Potassium Channel
Shipping Temperature	Room Temperature
Molecular Weight	681.77
Product Description	Amiodarone (hydrochloride) (Standard) is the analytical standard of Amiodarone (hydrochloride). This product is intended for research and analytical applications. Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ∼45 nM[1]. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts[2]. Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias[1].
Manufacturer - Research Area	Cardiovascular Disease; Cancer
Solubility	DMSO : 24.5 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	Autophagy; Membrane Transporter/Ion Channel
Clinical information	Launched

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