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Bedaquiline

Bedaquiline

Item no.	HY-14881-1mg
Manufacturer	MedChem Express
CASRN	843663-66-1
Amount	1 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Metabolism Cholesterol & Lipid Metabolism Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.98
Citations	[1]Jang JC, et al. Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis. J Microbiol. 2017 Apr 20.\|[2]Pang Y, et al. In Vitro Activity of Bedaquiline against Nontuberculous Mycobacteria in China. Antimicrob Agents Chemother. 2017 Apr 24;61(5).\|[3]Chahine EB, et al. Bedaquiline: a novel diarylquinoline for multidrug-resistant tuberculosis. Ann Pharmacother. 2014 Jan;48(1):107-15.\|[4]Sarathy JP, et al. TBAJ-876 displays Bedaquiline-like mycobactericidal potency without retaining the parental drug's uncoupler activity. Antimicrob Agents Chemother. 2019 Nov 11. ACS Chem Biol. 2021 Dec 15.\|ACS Infect Dis. 2020 Dec 15.\|ACS Infect Dis. 2024 Jan 18.\|Advanced Biochemistry, University of Madras, American.2019, Jan\|Antimicrob Agents Chemother. 2019 Sep 23;63(10):e01191-19.\|Antimicrob Agents Chemother. 2020 Jan 27;64(2):e01540-19.\|Antimicrob Agents Chemother. 2020 Mar 24;64(4):e02404-19.\|Antimicrob Agents Chemother. 2021 Jan 25;AAC.01445-20.\|Antimicrob Agents Chemother. 2021 Jun 21;AAC0095621.\|Antimicrob Agents Chemother. 2023 Jan 23;e0145922.\|Antimicrob Agents Chemother. 2024 Oct 29:e0094524.\|Antimicrob Agents Chemother. 2024 Oct 29:e0105124.\|bioRxiv. 2024 Oct 30:2024.10.30.620736.\|bioRxiv. 2025 February 06.\|Cell. 2023 May 11;186(10):2176-2192.e22.\|Commun Biol. 2025 Feb 6;8(1):187.\|Dis Model Mech. 2021 Oct 13;dmm.049145.\|Eur J Med Chem. 6 August 2022, 114639.\|Front Cell Infect Microbiol. 2016 Nov 8;6:145. eCollection 2016.\|Front Microbiol. 2018 Aug 15;9:1898. \|Front Microbiol. 2021 Feb 25;12:647611.\|Int J Pharm. 2024 Feb 21:653:123920.\|J Biol Chem. 2024 Jan 2:105618.\|J Pharm Biomed Anal. 2023 Oct 25, 235, 115658.\|Mbio. 2021 Jun 1;e0108821.\|Microbiol Spectr. 2021 Jun 16;e0004521.\|Microbiol Spectr. 2023 Nov 20:e0228223.\|Nanomedicine. 2025 Mar 18:1-13.\|Nat Commun. 2021 Jun 21;12(1):3816.\|Pharmaceuticals. 2023 Sep 15, 16(9), 1309.\|Research Square Preprint. 2021 Nov.\|Research Square Preprint. 2022 Feb.\|Research Square Preprint. 2023 May 2.\|SLAS Discov. 2020 Sep;25(8):895-905.\|University of Manitoba. Department of Medical Microbiology and Infectious Diseases. 2022 Jan.\|Vet Res. 2023 Dec 19;54(1):123.\|Zoonoses. 2023 Feb 2.\|ACS Infect Dis. 2024 Aug 13.\|Università Vita-Salute San Raffaele. 2022 Apr 08. 34.
Smiles	BrC1=CC=C(N=C(OC)C([C@H]([C@@](C2=CC=CC3=C2C=CC=C3)(O)CCN(C)C)C4=CC=CC=C4)=C5)C5=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	TMC207,R207910
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Antibiotic; Bacterial
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	555.50
Product Description	Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit[1]. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis[2].
Manufacturer - Research Area	Infection
Solubility	DMSO: 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Anti-infection
Clinical information	Launched

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HY-14881-1mg-safety-datasheet.pdf