TH470

Item no.	HY-151539-10mM
Manufacturer	MedChem Express
CASRN	2834739-51-2
Amount	10 mM/1 mL
Quantity options	10 mM/1 mL 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.57
Citations	[1]Hanke T, et al. Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes. J Med Chem. 2022 Oct 13;65(19):13264-13287.
Smiles	CC(C(NC1=NC=C(S1)C(NCCN(C(C2=CC=C(C=C2)S(=O)(NC3=CC=CC=C3)=O)=O)CC4=CC=CC=C4)=O)=O)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	LIM Kinase (LIMK)
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	605.73
Product Description	TH470 is a highly selective LIMK1/2 (LIM kinase1/2) inhibitor (LIMK1 IC50=9.8 nM; LIMK2 IC50=13 nM), and can be used in orphan disease research[1].
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage
Isoform	LIMK1; LIMK2
Clinical information	No Development Reported

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HY-151539-10mM-safety-datasheet.pdf