KN-92

Item no.	HY-15517-1mg
Manufacturer	MedChem Express
CASRN	176708-42-2
Amount	1 mg
Quantity options	100 mg 10 mg 1 ea 1 mg 25 mg 2 mg 50 mg 5 mg
Category	Oncology Food Safety Histamines Neuroscience Metabolism Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer
Type	Inhibitors
Specific against	other
Purity	99.91
Citations	Cell Calcium. 2021 Oct 5;100:102483. Commun Biol. 2025 Mar 12;8(1):417. J Mol Cell Cardiol. 2021 Nov 10;S0022-2828(21)00210-8. J Endocrinol. 2018 Mar;236(3):151-165. Nat Metab. 2020 Sep;2(9):918-933. Sci Rep. 2023 Dec 7;13(1):21712. [1]Smyth JT, et al. Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+/calmodulin-dependent protein kinase II antagonism. J Biol Chem. 2002;277(38):35061-35070. [2]An P, et al. KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro. World J Gastroenterol. 2007;13(9):1445-1448.
Smiles	O=S(C1=CC=C(OC)C=C1)(NC2=CC=CC=C2CN(C/C=C/C3=CC=C(Cl)C=C3)C)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	CaMK
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	456.98
Product Description	KN-92 is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a cell-permeable, reversible and competitive CaMKII inhibitor[1][2].
Manufacturer - Research Area	Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Neuronal Signaling
Clinical information	No Development Reported

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