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INT-777

INT-777

Item no.	HY-15677-1mg
Manufacturer	MedChem Express
CASRN	1199796-29-6
Amount	1 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Neural Transcription Factors Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Other Lipid\Cholesterol Metabolism Modulators
Type	Inhibitors
Specific against	other
Purity	98.0
Citations	[1]Pellicciari R, et al. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem. 2009 Dec 24;52(24):7958-61. [2]Thomas C, et al. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab. 2009 Sep;10(3):167-77. [3]Duboc H, et al.Reduction of epithelial secretion in male rat distal colonic mucosa by bile acid receptor TGR5 agonist, INT-777: role of submucosal neurons. Neurogastroenterol Motil. 2016 Jun 3. doi: 10.1111/nmo. [4]Baiqiang Li, et al. INT-777, a bile acid receptor agonist, extenuates pancreatic acinar cells necrosis in a mouse model of acute pancreatitis. Biochem Biophys Res Commun. 2018 Sep 3;503(1):38-44.
Smiles	O[C@@H]1CC[C@@]2(C)[C@@]([C@@H](CC)[C@@H](O)[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@@H]4[C@H](C)C[C@H](C)C(O)=O)([H])C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	S-EMCA
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Targets	G protein-coupled Bile Acid Receptor 1
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	450.65
Product Description	INT-777 is a potent TGR5 agonist with an EC50 of 0.82 μM[1].
Manufacturer - Research Area	Endocrinology
Solubility	DMSO : ≥ 31 mg/mL\|Ethanol : ≥ 50 mg/mL
Manufacturer - Pathway	GPCR/G Protein
Clinical information	No Development Reported

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HY-15677-1mg-safety-datasheet.pdf