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MYC degrader 1

MYC degrader 1

Item no.	HY-162318-25mg
Manufacturer	MedChem Express
CASRN	2946670-96-6
Amount	25 mg
Quantity options	1 ea 10 mg 1 mg 25 mg 5 mg
Category	Reagents & Chemicals Standards, Ladders & Markers
Type	Standard
Specific against	other
Purity	99.61
Citations	[1]Ma J, et al. MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation. Nat Commun. 2024 Feb 29;15(1):1871.
Smiles	ClC1=CC(C2=CC(C(F)(F)F)=C(N3CCC(CNCC4=CC(CN(C5C(NC(CC5)=O)=O)C6=O)=C6C=C4)CC3)N=C2)=CC=C1
ECLASS 10.1	42021590
ECLASS 11.0	42021590
UNSPSC	12352202
Shipping condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	c-Myc; Molecular Glues
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, sealed storage, away from moisture and light)
Product Description	MYC degrader 1 (compound A80.2HCl) is an orally available MYC molecular glues degrader with anti-tumor activity. MYC degrader 1 restores pRB1 protein activity and re-establishes sensitivity of MYC overexpressing cancer cells to CDK4/6 inhibitors[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; PROTAC
Clinical information	No Development Reported

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