Comparison

3PO European Partner

Item no. HY-19824-25mg
Manufacturer MedChem Express
CASRN 18550-98-6
Amount 25 mg
Quantity options 100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category
Type Inhibitors
Specific against other
Purity 99.85
Citations [1]Clem B, et al. Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol Cancer Ther. 2008 Jan;7(1):110-20.|[2]Schoors S, et al. Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. Cell Metab. 2014 Jan 7;19(1):37-48.|[3]Lea MA, Inhibition of Growth of Bladder Cancer Cells by 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one in Combination with Other Compounds Affecting Glucose Metabolism. Anticancer Res. 2015 Nov;35(11):5889-99.
Smiles O=C(C1=CC=NC=C1)/C=C/C2=CC=CN=C2
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Shipping Condition Room temperature
Available
Manufacturer - Type
Reference compound
Manufacturer - Applications
Cancer-programmed cell death
Manufacturer - Targets
Autophagy
Shipping Temperature
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight
210.23
Product Description
3PO is an inhibitor of PFKFB3. 3PO attenuates the proliferation of several cancer cell lines with IC50s of 1.4-24 μmol/L. 3PO suppresses glucose uptake and decreases the intracellular concentration of Fru-2, 6-BP, lactate, ATP, NAD+ and NADH. 3PO can be used for the research of cancer[1].
Manufacturer - Research Area
Cancer
Solubility
DMSO: 60 mg/mL (ultrasonic)
Manufacturer - Pathway
Autophagy
Clinical information
No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 25 mg
Available: In stock
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