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Palbociclib (monohydrochloride)

Palbociclib (monohydrochloride)

Item no.	HY-50767A-2g
Manufacturer	MedChem Express
CASRN	827022-32-2
Amount	2 g
Quantity options	100 mg 10 mM/1 mL 10 mg 1 g 1 mg 200 mg 2 g 500 mg 50 mg 5 mg
Specific against	other
Purity	99.98
Smiles	O=C1C(C(C)=O)=C(C)C2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5.Cl
Alias	PD 0332991 (monohydrochloride)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	CDK
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	483.99
Product Description	Palbociclib (PD 0332991) monohydrochloride is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib monohydrochloride has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma[1][3][4].
Manufacturer - Research Area	Cancer
Solubility	DMSO : 4.63 mg/mL (ultrasonic; warming; heat to 80°C)\|H2O : 1 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Cell Cycle/DNA Damage
Clinical information	Launched
Isoform	CDK4; CDK6

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HY-50767A-2g-safety-datasheet.pdf