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Erlotinib

Erlotinib

Item no.	HY-50896-5g
Manufacturer	MedChem Express
CASRN	183321-74-6
Amount	5 g
Quantity options	100 mg 10 mM/1 mL 1 g 500 mg 5 g
Specific against	other
Purity	99.99
Smiles	C#CC1=CC=CC(NC2=NC=NC3=C2C=C(C(OCCOC)=C3)OCCOC)=C1
Alias	CP-358774,NSC 718781,OSI-774
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Autophagy; EGFR
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	393.44
Product Description	Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1]. Erlotinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Manufacturer - Research Area	Cancer
Solubility	DMSO : 3.94 mg/mL (ultrasonic; warming; heat to 40°C)
Manufacturer - Pathway	Autophagy; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Clinical information	Launched
Isoform	EGFR/ErbB1/HER1

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