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BAY 61-3606 (hydrochloride)

BAY 61-3606 (hydrochloride)

Item no.	HY-76474A-1mg
Manufacturer	MedChem Express
CASRN	1615197-10-8
Amount	1 mg
Quantity options	10 mg 1 mg 25 mg 5 mg
Category	Reagents & Chemicals Standards, Ladders & Markers
Type	Standard
Specific against	other
Purity	98.98
Smiles	NC(C1=C(N=CC=C1)NC2=NC(C3=CC(OC)=C(C=C3)OC)=CC4=NC=CN24)=O.Cl
ECLASS 10.1	42021590
ECLASS 11.0	42021590
UNSPSC	12352202
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Targets	Apoptosis; Syk
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Product Description	BAY 61-3606 hydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM and an IC50 of 10 nM . BAY 61-3606 hydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 hydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates. BAY 61-3606 hydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.
Manufacturer - Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO : 25 mg/mL (ultrasonic; warming; heat to 160°C)
Manufacturer - Pathway	Apoptosis; Protein Tyrosine Kinase/RTK
Clinical information	No Development Reported

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