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(Rac)-5-Hydroxymethyl Tolterodine (hydrochloride) European Partner

Item no. HY-76570A-500mg
Manufacturer MedChem Express
CASRN 250214-40-5
Amount 500 mg
Quantity options 100 mg 1 ea 1 g 500 mg
Category
Type Molecules
Specific against other
Purity 97.84
Citations [1]L Nilvebrant, et al. Antimuscarinic potency and bladder selectivity of PNU-200577, a major metabolite of tolterodine. Pharmacol Toxicol. 1997 Oct;81(4):169-72.|[2]B Malhotra, et al. The design and development of fesoterodine as a prodrug of 5-hydroxymethyl tolterodine (5-HMT), the active metabolite of tolterodine. Curr Med Chem. 2009;16(33):4481-9.|[3]Shizuo Yamada, et al. Muscarinic receptor binding of fesoterodine, 5-hydroxymethyl tolterodine, and tolterodine in rat tissues after the oral, intravenous, or intravesical administration. J Pharmacol Sci. 2019 May;140(1):73-78.
Smiles [H]Cl.OC1=C(C=C(CO)C=C1)C(C2=CC=CC=C2)CCN(C(C)C)C(C)C
ECLASS 10.1 32169090
ECLASS 11.0 32169090
UNSPSC 12000000
Alias (Rac)-Desfesoterodine (hydrochloride),(Rac)-PNU-200577 (hydrochloride)
Shipping Condition Room temperature
Available
Manufacturer - Type
Reference compound
Manufacturer - Applications
Neuroscience-Neuromodulation
Manufacturer - Targets
mAChR
Shipping Temperature
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Molecular Weight
377.95
Product Description
(Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine) hydrochloride, an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine hydrochloride can be used for overactive bladder research[1].
Manufacturer - Research Area
Neurological Disease
Solubility
10 mM in DMSO
Manufacturer - Pathway
GPCR/G Protein; Neuronal Signaling
Isoform
mAChR1; mAChR3; mAChR4; mAChR5
Clinical information
No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 500 mg
Available: In stock
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