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Chenodeoxycholic Acid

Chenodeoxycholic Acid

Item no.	HY-76847-5g
Manufacturer	MedChem Express
CASRN	474-25-9
Amount	5 g
Quantity options	100 mg 10 g 10 mM/1 mL 1 g 500 mg 5 g
Category	Oncology Neuroscience Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Neural Signaling Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Testicular & Prostate Cancer Other Lipid\Cholesterol Metabolism Modulators
Type	Inhibitors
Specific against	other
Purity	99.93
Citations	[1]Stauffer AT, et al. Chenodeoxycholic acid and deoxycholic acid inhibit 11 beta-hydroxysteroid dehydrogenase type 2 and cause cortisol-induced transcriptional activation of the mineralocorticoid receptor. J Biol Chem. 2002 Jul 19;277(29):26286-92\|[2]Casaburi I, et al. Chenodeoxycholic acid through a TGR5-dependent CREB signaling activation enhances cyclin D1 expression and promotes human endometrial cancer cell proliferation. Cell Cycle. 2012 Jul 15;11(14):2699-710\|[3]Kawabe Y, et al. The molecular mechanism of the induction of the low density lipoprotein receptor by chenodeoxycholic acid in cultured human cells. Biochem Biophys Res Commun. 1995 Mar 8;208(1):405-11.\|[4]Ao M, et al. Chenodeoxycholic acid stimulates Cl(-) secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells. Am J Physiol Cell Physiol. 2013 Aug 15;305(4):C447-56\|[5]Noh K, et al. Farnesoid X receptor activation by chenodeoxycholic acid induces detoxifying enzymes through AMP-activated protein kinase and extracellular signal-regulated kinase 1/2-mediated phosphorylation of CCAAT/enhancer binding protein β. Drug Metab
Smiles	O=C(O)CC[C@@H](C)[C@]1([H])[C@]2(C)[C@](CC1)([H])[C@]3([H])[C@H](O)C[C@@](C4)([H])[C@@](CC[C@H]4O)(C)[C@]([H])3CC2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CDCA
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Autophagy; Endogenous Metabolite; FXR
Shipping Temperature	Room Temperature
Storage Conditions	RT, protect from light
Molecular Weight	392.57
Product Description	Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
Manufacturer - Research Area	Metabolic Disease; Cancer
Solubility	0.1 M NaOH: 50 mg/mL (ultrasonic; adjust pH to 8 with NaOH)\|DMSO: ≥ 50 mg/mL
Manufacturer - Pathway	Autophagy; Metabolic Enzyme/Protease
Isoform	Human Endogenous Metabolite
Clinical information	Launched

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HY-76847-5g-safety-datasheet.pdf