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Pentamidine

Pentamidine

Item no.	HY-B0537-25mg
Manufacturer	MedChem Express
CASRN	100-33-4
Amount	25 mg
Quantity options	100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Skin Cancer Colorectal Cancer
Type	Inhibitors
Specific against	other
Purity	97.19
Citations	[1]Pathak MK, et al. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther. 2002 Dec;1(14):1255-64.\|[2]Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2(10): p. 1387-400.\|[3]Sands M, et al. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7(5):625-34.\|[4]David C. Bean, et al. Pentamidine: a drug to consider re-purposing in the targeted treatment of multi-drug resistant bacterial infections? J Lab Precis Med 2017;2:49. Biochem Biophys Res Commun. 2019 Sep 17;517(2):221-226.\|BMC Womens Health. 2022 Nov 24;22(1):470.\|Drug Des Dev Ther. 2021 Jul 1;15:2857-2868.\|Immunity. 2023 Feb 14;56(2):272-288.e7.\|Int J Mol Sci. 2023 Sep 5, 24(18), 13812.\|Microbiol Spectr. 2023 May 1;e0313822.\|Molecules. 2020 Apr 23;25(8):1980.\|Cell Rep Methods. 2023 Oct 23;3(10):100599.
Smiles	N=C(C1=CC=C(OCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)N
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	MP-601205
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Antibiotic; Bacterial; Fungal; Parasite; Phosphatase
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	340.42
Product Description	Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].
Manufacturer - Research Area	Cancer; Infection
Solubility	DMSO: 3.3 mg/mL (ultrasonic; warming; adjust pH to 6 with 1 M HCl; heat to 60°C)
Manufacturer - Pathway	Anti-infection; Metabolic Enzyme/Protease
Isoform	Leishmania; Trypanosoma
Clinical information	Launched

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HY-B0537-25mg-safety-datasheet.pdf