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Pilocarpine (Hydrochloride)

Pilocarpine (Hydrochloride)

Item no.	HY-B0726-1g
Manufacturer	MedChem Express
CASRN	54-71-7
Amount	1 g
Quantity options	100 mg 10 g 10 mMx1 mL 1 g 500 mg 50 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.98
Citations	[1]Matsuzaki K, et al. Daily voluntary exercise enhances pilocarpine-induced saliva secretion and aquaporin 1 expression in rat submandibular glands. FEBS Open Bio. 2017 Dec 7;8(1):85-93.\|[2]Yuan XL, et al. Cytotoxicity of pilocarpine to human corneal stromal cells and its underlying cytotoxic mechanisms. Int J Ophthalmol. 2016 Apr 18;9(4):505-11.\|[3]Tonta MA, et al. Pilocarpine-induced relaxation of rat tail artery by a non-cholinergic mechanism and in the absence of an intact endothelium. Br J Pharmacol. 1994 Jun;112(2):525-32.\|[4]Wang RF, et al. Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus. Epilepsy Res. 2018 Mar 9;142:45-52. Acta Pharmacol Sin. 2024 Jul 25.\|Brain Res. 2023 Apr 29;148382.\|Brain Sci. 2023, 13(2), 262.\|Cell Mol Neurobiol. 2020 Oct 15. \|Cell Rep. 2025 Feb 23;44(3):115343.\|Cells. 2024 Oct 1;13(19):1635.\|Commun Biol. 2024 Sep 17;7(1):1158.\|Epilepsy Res. 2018 May;142:45-52. \|Exp Eye Res. 2024 Jul 16:110008.\|Food Chem. 30 November 2022, 133593.\|Immunity. 2022 Jul 12;S1074-7613(22)00291-6.\|Int Immunopharmacol. 2022 Aug 22;111:109152.\|Int Immunopharmacol. 2024 Jan 5:128:111485.\|J Mol Neurosci. 2020 Nov;70(11):1858-1870.\|Neuropharmacology. 2017 May 1;117:238-248.\|Neuroscience. 2021 Feb 10;455:212-222.\|Research Square Preprint. 2021 Aug.\|BMC Immunol. 2024 Feb 12;25(1):16.\|Cell Rep. 2023 Apr 30;42(5):112456.\|FASEB J. 2024 Aug 15;38(15):e23878.\|Int J Mol Sci. 2023 Apr 12;24(8):7171.\|Int J Mol Sci. 2023 Apr 16, 24(8), 7356.\|Int J Mol Sci. 2024 Sep 27;25(19):10432.\|J Nanobiotechnology. 2025 Mar 20;23(1):228.\|Life Sci. 2022 Nov 1;308:120942.\|Mol Cell Endocrinol. 2025 Jan 21:599:112464.\|Mol Immunol. 2024 Jun 19:172:68-75.\|Neurochem Int. 2024 Jan 28:174:105677.\|Ocul Surf. 2024 Sep 27:S1542-0124(24)00104-6.\|Prog Neurobiol. 2022 Aug 2;102335.\|Research Square Preprint. 2023 Apr 13.\|Research Square Print. December 16th, 2022.
Smiles	CN1C(C[C@@H](COC2=O)[C@@H]2CC)=CN=C1.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	mAChR
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	244.72
Product Description	Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
Manufacturer - Research Area	Neurological Disease; Cancer; Cardiovascular Disease
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: ≥ 37 mg/mL
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Isoform	mAChR3
Clinical information	Launched

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HY-B0726-1g-safety-datasheet.pdf