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Gangliotetraose

Gangliotetraose

Item no.	HY-N10512-5mg
Manufacturer	MedChem Express
CASRN	75645-24-8
Amount	5 mg
Quantity options	1 ea 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Citations	[1]Okada H, et al. Complement-mediated cytolysis and azidothymidine are synergistic in HIV-1 suppression. Int Immunol. 1998 Jan;10(1):91-5. \|[2]Ledeen RW, et al. The role of GM1 and other gangliosides in neuronal differentiation. Overview and new finding. Ann N Y Acad Sci. 1998 Jun 19;845:161-75. \|[3]Zakharova IO, et al. GM1 ganglioside activates ERK1/2 and Akt downstream of Trk tyrosine kinase and protects PC12 cells against hydrogen peroxide toxicity. Neurochem Res. 2014 Nov;39(11):2262-75. \|[4]Toffano G, et al. GM1 ganglioside stimulates the regeneration of dopaminergic neurons in the central nervous system. Brain Res. 1983 Feb 14;261(1):163-6.
Smiles	CC(N[C@H]([C@H]([C@H]([C@H](O1)CO)O)O[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2O)O)O)CO)[C@@H]1O[C@H]3[C@H](O[C@H]([C@@H]([C@H]3O)O)O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)CO)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Gg4
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Targets	Others
Shipping Temperature	Room temperature
Molecular Weight	707.63
Product Description	Gangliotetraose (Gg4) is a tetrasccharide, exhibits major components including GM1 and its sialylated derivatives. GM1 facilitates efflux of nuclear Ca2+ and reduces the level of nuclear Ca2+ that characterizes the differentiated neuron. GM1 affects neuronal plasticity and repair mechanisms, as well as neurotrophin release in the brain[1][2].
Manufacturer - Research Area	Neurological Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	Others
Clinical information	No Development Reported

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