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Paris saponin VII (Standard)

Paris saponin VII (Standard)

Item no.	HY-N3584R-5mg
Manufacturer	MedChem Express
CASRN	68124-04-9
Amount	5 mg
Quantity options	1 ea 100 mg 10 mg 25 mg 50 mg 5 mg
Category	Food Safety Reagents & Chemicals Standards, Ladders & Markers Other Standards Food Additives Acidity Regulators
Type	Standard
Specific against	other
Citations	[1]Yan T, et al. Paris saponin VII induces cell cycle arrest and apoptosis by regulating Akt/MAPK pathway and inhibition of P-glycoprotein in K562/ADR cells. Phytother Res. 2018 May;32(5):898-907.\|[2]Li Y, et al. Paris saponin VII reverses chemoresistance in breast MCF-7/ADR cells. J Ethnopharmacol. 2019 Mar 25;232:47-54.\|[3]Yan T, et al. Paris saponin VII induces cell cycle arrest and apoptosis by regulating Akt/MAPK pathway and inhibition of P-glycoprotein in K562/ADR cells. Phytother Res. 2018 May;32(5):898-907.\|[4]Li Y, et al. Paris saponin VII reverses chemoresistance in breast MCF-7/ADR cells. J Ethnopharmacol. 2019 Mar 25;232:47-54.
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ECLASS 10.1	42021590
ECLASS 11.0	42021590
UNSPSC	12352202
Alias	Chonglou Saponin VII (Standard)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference Standards
Manufacturer - Category	Reference compound / Active compounds; Natural Products
Manufacturer - Targets	Akt; Apoptosis; Autophagy; Bcl-2 Family; Caspase; p38 MAPK; PARP; P-glycoprotein; Reference Standards
Shipping Temperature	Room temperature
Molecular Weight	1031.18
Product Description	Paris saponin VII (Standard) is the analytical standard of Paris saponin VII. This product is intended for research and analytical applications. Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia[1].
Manufacturer - Research Area	Cancer
Manufacturer - Pathway	Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Others; PI3K/Akt/mTOR
UNSPSC Code	12352005

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