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D-GsMTx4

D-GsMTx4

Item no.	HY-P1410B-500ug
Manufacturer	MedChem Express
Amount	500 ug
Quantity options	1 ea 100 ug 1 mg 500 ug
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	99.59
Citations	[1]Alcaino C, Knutson K, Gottlieb PA, Farrugia G, Beyder A. Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4. Channels (Austin). 2017 May 4;11(3):245-253. doi: 10.1080/19336950.2017.1279370. Epub 2017 Jan 13. Erratum for: Addendum to: Wang F, Knutson K, Alcaino C, Linden DR, Gibbons SJ, Kashyap PK, Grover M, Oeckler R, Gottlieb PA, Li HJ, et al. Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces. J Physiol. 2017; 595(1):79-91\|[2]Eddy V A, et al. PIEZO2 Signal Transduction Mechanism and Potential Therapeutic Strategies for Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine, 2025, 211(Abstracts): A4722-A4722. \|[3]Liu L, et al. Piezo2 Channel Upregulation is Involved in Mechanical Allodynia in CYP-Induced Cystitis Rats. Mol Neurobiol. 2023 Sep;60(9):5000-5012.\|[4]Jo MJ, et al. Blockade of Piezo2 Pathway Attenuates Inflammatory and Neuropathic Pain in the Orofacial Area. Pain Res Manag. 2024 Sep 27;2024:9179928.
Smiles	O=C(CN)N[C@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N1[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H]2CSSC[C@H](NC3=O)C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N)=O)CC4=CC=CC=C4)=O)CO)=O)CC5=CC=CC=C5)=O)CC(N)=O)=O)=O)CCCCN)=O)CC(O)=O)=O)CC(O)=O)=O)CC(N)=O)=O)CCC1)=O)CC(N)=O)=O)CSSC[C@H](NC6=O)C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H]3CC(C)C)=O)CCCCN)=O)CC7=CC=CC=C7)=O)CC(C)C)=O)CCCCN)=O)CO)=O)=O)CCCCN)=O)CC8=CNC9=CC=CC=C89)=O)CC%10=CNC%11=CC=CC=C%10%11)=O)CC%12=CC=CC=C%12)=O)CCC(O)=O)=O)CC(C)C)=O)CSSC[C@H](NC2=O)C(N[C@@H](C(N%13[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H]6CCCCN)=O)CC(C)C)=O)CCCCN)=O)CCC%13)=O)CCCNC(N)=N)=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Type	Peptides
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Akt; Calcium Channel; mTOR; PI3K; Piezo Channel
Shipping Temperature	Blue Ice
Storage Conditions	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Molecular Weight	4095.84
Product Description	D-GsMTx4 is a spider peptide and the D enantiomer of GsMTx4 (HY-P1410). D-GsMTx4 inhibits the mechanosensitive ion channel Piezo2. D-GsMTx4 inhibits [Ca2+]i elevation. D-GsMTx4 inhibits mTOR and PI3K-Akt signaling pathways. D-GsMTx4 inhibits mechanical allodynia and thermal hyperalgesia. D-GsMTx4 can be used in researches of mechanical stress, chronic pain and idiopathic pulmonary fibrosis[1][2][3][4].
Manufacturer - Research Area	Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling; PI3K/Akt/mTOR
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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