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Mambalgin 1 (TFA)

Mambalgin 1 (TFA)

Item no.	HY-P1441A-100ug
Manufacturer	MedChem Express
Amount	100 ug
Quantity options	100 mg 100 ug 1 ea 500 ug
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	95.72
Smiles	OC(C(F)(F)F)=O.O=C(N[C@@H](CCCCN)C(N[C@@H](CSS(C)CC[C@@H](C(N[C@@H](CCCCN)C(N[C@H]1CC2=CC=CC=C2)=O)=O)NC3=O)C(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC5=CNC=N5)C(NCC(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC6=CC=C(C=C6)O)C(N[C@@H](CC7=CNC=N7)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CCS8C)C(N9[C@@H](CCC9)C(N[C@@H](CC%10=CC=CC=C%10)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](CS8)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CS)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)NC%11=O)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N[C@H]%11CS)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC1=O)C(N[C@@H](CC%12=CNC=N%12)C(N[C@@H](CCCNC(N)=N)C(N[C@H]3CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Type	Peptides
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Sodium Channel
Shipping Temperature	Blue Ice
Storage Conditions	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Molecular Weight	6554.54 (free acid)
Product Description	Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC50 values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.
Manufacturer - Research Area	Neurological Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	Membrane Transporter/Ion Channel
Isoform	Nav1.8
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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