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ALK-1, Cynomolgus (HEK293, His)

ALK-1, Cynomolgus (HEK293, His)

Item no.	HY-P75569-50ug
Manufacturer	MedChem Express
Amount	50 ug
Quantity options	100 ug 10 ug 1 ea 20 ug 2 ug 50 ug
Category	Inhibitors & Compound Libraries Compound Libraries
Type	Peptides
Specific against	other
Purity	98.0
Sequence	DPVKPSRGPL VTCTCESPHC RGPTCQGAWC TVVLVREEGR HPQEHRGCGN LHRELCRGRP TEFVNHYCCD SHLCNRNVSL VLEATQTPSE QPGTDSQ
Citations	[1]S P Oh, et al. Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2626-31. [2]Dianyuan Zhao, et al. ALK1 signaling is required for the homeostasis of Kupffer cells and prevention of bacterial infection. J Clin Invest. 2022 Feb 1;132(3):e150489. [3]Dianne Mitchell, et al. ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth. Mol Cancer Ther. 2010 Feb;9(2):379-88. [4]Kerstin Wöltje, et al. Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells. PLoS One. 2015 Mar 23;10(3):e0120547.
Smiles	DPVKPSRGPL VTCTCESPHC RGPTCQGAWC TVVLVREEGR HPQEHRGCGN LHRELCRGRP TEFVNHYCCD SHLCNRNVSL VLEATQTPSE QPGTDSQ
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	ALK-1 Protein, Cynomolgus (HEK293, His),Cynomolgus,HEK293
Shipping condition	Cool pack
Available
Manufacturer - Type	Recombinant Proteins
Shipping Temperature	Blue Ice
Storage Conditions	Stored at -20°C for 2 years
Molecular Weight	Approximately 21-25 kDa due to the glycosylation.
Product Description	ALK-1, also known as ACVRL1, is a type I receptor for TGF-β superfamily with 2 ligands, BMP9 and BMP10. ALK-1 is predominantly expressed in endothelial cells and plays a critical role in regulating developmental and pathological angiogenesis[1][2]. ALK-1 Protein, Cynomolgus (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It consists of 118 amino acids (D22-Q118).

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