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MCU-i11

MCU-i11

Item no.	HY-W194810-25mg
Manufacturer	MedChem Express
CASRN	902903-59-7
Amount	25 mg
Quantity options	1 ea 10 mM/1 mL 10 mg 1 mg 25 mg 5 mg
Category	Reagents & Chemicals Standards, Ladders & Markers
Type	Standard
Specific against	other
Purity	98.42
Citations	[1]Di Marco G, et al. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6.\|[2]Marmolejo-Garza A, et al. Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis. Cell Death Dis. 2023 Nov 25;14(11):772.\|[3]Serrat R, et al. Astroglial ER-mitochondria calcium transfer mediates endocannabinoid-dependent synaptic integration. Cell Rep. 2021 Dec 21;37(12):110133.
Smiles	O=C(NC1=CC=C(OCC)C=C1)CN2C(N(CC3=CC=CC=C3)C(C4=C2SC5=C4CCN(C(C)=O)C5)=O)=O
ECLASS 10.1	42021590
ECLASS 11.0	42021590
UNSPSC	12352202
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	Calcium Channel; Mitochondrial Metabolism
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	532.61
Product Description	MCU-i11 is a negative regulator of the mitochondrial calcium uniporter (MCU) complex. MCU-i11 can reduce mitochondrial Ca2+ uptake. MCU-i11 impairs muscle cell growth. MCU-i11 can be used to study breast cancer, cervical cancer and neurological diseases[1][2][3].
Manufacturer - Research Area	Cancer; Neurological Disease
Solubility	DMSO: 87.5 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-W194810-25mg-safety-datasheet.pdf