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p-SCN-Bn-NOTA (trihydrochloride)

p-SCN-Bn-NOTA (trihydrochloride)

Item no.	HY-W782083-10mg
Manufacturer	MedChem Express
CASRN	1583289-85-3
Amount	10 mg
Quantity options	1 ea 10 mg 25 mg 5 mg
Category	Reagents & Chemicals Other Chemicals
Type	Chemical Reagents
Specific against	other
Purity	99.62
Citations	[1]Craft JM, et al. In vitro and in vivo evaluation of a 64Cu-labeled NOTA-Bn-SCN-Aoc-bombesin analogue in gastrin-releasing peptide receptor expressing prostate cancer. Nucl Med Biol. 2012 Jul;39(5):609-16.\|[2]Yun M, et al. A High-Affinity Repebody for Molecular Imaging of EGFR-Expressing Malignant Tumors. Theranostics. 2017 Jun 25;7(10):2620-2633.
Smiles	O=C(O)CN1C(CC2=CC=C(N=C=S)C=C2)CN(CC(O)=O)CCN(CC(O)=O)CC1.Cl.Cl.Cl
ECLASS 10.1	42020190
ECLASS 11.0	42020190
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Type	Biochemical Assay Reagents
Manufacturer - Targets	Biochemical Assay Reagents; Bombesin Receptor; EGFR; Radionuclide-Drug Conjugates (RDCs)
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	559.89
Product Description	p-SCN-Bn-NOTA trihydrochloride is a macrocyclic chelator. p-SCN-Bn-NOTA trihydrochloride can be covalently coupled to molecules such as peptides through the thiocyanate group to form hexacoordinate copper (such as 64Cu) complexes. p-SCN-Bn-NOTA trihydrochloride specifically binds to GRPR or EGFR highly expressed on the surface of tumor cells, mediating tumor enrichment of radioactive probes. p-SCN-Bn-NOTA trihydrochloride can be used to study malignant tumors expressing GRPR or EGFR, such as prostate cancer and colorectal cancer[1][2].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 125 mg/mL (ultrasonic)
Manufacturer - Pathway	Antibody-drug Conjugate/ADC Related; GPCR/G Protein; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK
Isoform	RDC Bifunctional Chelator
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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