lipid 14

LIPID 14 is a novel ionizable lipid used for mRNA delivery.In 2021, Elia et al. used lipid 2 LNPs and lipid 14 LNPs to deliver mRNA encoding SARSCoV-2 human Fc-conjugated receptor binding domain (RBDhFc
mRNA). While both lipid 274 LNP RBD-hFc mRNA and
lipid 14 LNP RBD-hFc mRNA induced equal cellular and
humoral responses in mice at an mRNA dose of 5 μg, only lipid
14 LNP RBD-hFc mRNA exhibited strong immunogenicity
following intradermal administration. Both intradermal administration
and intramuscular administration of lipid 14 LNPs
could activate antigen presenting cells (APCs), thus inducing
cellular responses.