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(Rac)-Nutlin-3

(Rac)-Nutlin-3

Item no.	HY-10029A-10mg
Manufacturer	MedChem Express
CASRN	890090-75-2
Amount	10 mg
Quantity options	10 mg 1 ea 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Citations	[1]Crane EK, et al. Nutlin-3a: A Potential Therapeutic Opportunity for TP53 Wild-Type Ovarian Carcinomas. PLoS One. 2015 Aug 6;10(8):e0135101.\|[2]Tovar C, et al. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1888-93.\|[3]M Ulrich, et al. Murine tumor models for the in vivo evaluation of natural compounds and their derivatives as new cancer therapeutics. München. 2016.
Smiles	O=C(N1C(C2=C(C=C(C=C2)OC)OC(C)C)=NC(C3=CC=C(C=C3)Cl)C1C4=CC=C(C=C4)Cl)N5CC(NCC5)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	(Rac)-Rebemadlin
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis; Autophagy; E1/E2/E3 Enzyme; MDM-2/p53
Shipping Temperature	Room temperature
Molecular Weight	581.49
Product Description	(Rac)-Nutlin-3 (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor ( IC 50 =90 nM). (Rac)-Nutlin-3 inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis . (Rac)-Nutlin-3 has the potential for the study of TP53 wild-type ovarian carcinomas [1] [2] .
Manufacturer - Research Area	Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Apoptosis; Autophagy; Metabolic Enzyme/Protease
Clinical information	No Development Reported

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