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EUK-134

EUK-134

Item no.	HY-100594-10mM
Manufacturer	MedChem Express
CASRN	81065-76-1
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	98.27
Citations	[1]P Gianello, et al. EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. Transplantation. 1996 Dec 15;62(11):1664-6.\|[2]Mohamed Samai, et al. Comparison of the effects of the superoxide dismutase mimetics EUK-134 and tempol on paraquat-induced nephrotoxicity. Free Radic Biol Med. 2007 Aug 15;43(4):528-34.\|[3]Sreeja Purushothaman, et al. Mitoprotective antioxidant EUK-134 stimulates fatty acid oxidation and prevents hypertrophy in H9C2 cells. Mol Cell Biochem. 2016 Sep;420(1-2):185-94.
Smiles	COC1=CC=CC2=C1[O-][Mn+3]([Cl-])[O-]C(C(OC)=CC=C3)=C3/C=N/CC/N=C/2
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	NF-κB
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	416.74
Product Description	EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. EUK-134 is a superoxide dismutase (SOD) mimetics (SODm) with catalase activity. EUK-134 is a mitoprotective antioxidant. EUK-134 reduces the expression of NF-κB, MDA level, and protein carbonylation in H9C2 cells[1][2][3].
Manufacturer - Research Area	Cardiovascular Disease
Solubility	DMSO: 25 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O: 5 mg/mL (ultrasonic; warming; heat to 80°C)
Manufacturer - Pathway	NF-κB
Isoform	NF-κB
Clinical information	No Development Reported

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HY-100594-10mM-safety-datasheet.pdf