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CGS 15943

CGS 15943

Item no.	HY-100678-50mg
Manufacturer	MedChem Express
CASRN	104615-18-1
Amount	50 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.96
Citations	[1]Gao Y, et al. CGS 15943, an adenosine A2 receptor antagonist, reduces cerebral ischemic injury in the Mongolian gerbil. Life Sci. 1994;55(3):PL61-5.\|[2]Klotz KN, et al. Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):382-91.\|[3]Edling CE, et al. Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway. Cancer Biol Ther. 2014 May;15(5):524-32.
Smiles	NC1=NC2=C(C=C(Cl)C=C2)C3=NC(C4=CC=CO4)=NN13
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Adenosine Receptor; PI3K
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	285.69
Product Description	CGS 15943 is an orally bioavailable non-xanthine Adenosine Receptor antagonist. Its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM in transfected CHO cells, respectively. [1][2].
Manufacturer - Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO: 12.22 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein; PI3K/Akt/mTOR
Isoform	PI3Kγ; PI3Kδ
Clinical information	No Development Reported

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HY-100678-50mg-safety-datasheet.pdf