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Y-27632

Y-27632

Item no.	HY-10071-25mg
Manufacturer	MedChem Express
CASRN	146986-50-7
Amount	25 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 200 mg 25 mg 500 mg 50 mg 5 mg
Category	Cardiovascular Research Hypertension Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.91
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Rho-Associated Kinase Inhibitor (Y-27632) Attenuates Doxorubicin-Induced Apoptosis of Human Cardiac Stem Cells. PLoS One. 2015;10(12):e0144513. Published 2015 Dec 8.\|[7]Zhang L, et al. ROCK inhibitor Y-27632 suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells and increases their cloning efficiency. PLoS One. 2011;6(3):e18271. Published 2011 Mar 28.\|[8]Svoboda KK, et al. ROCK inhibitor (Y27632) increases apoptosis and disrupts the actin cortical mat in embryonic avian corneal epithelium. Dev Dyn. 2004;229(3):579-590. ACS Appl Mater Interfaces. 2022 May 25;14(20):23219-23231. ACS Biomater Sci Eng. 2022 Mar 14;8(3):1301-1311. ACS Biomater Sci Eng. 2023 Feb 13;9(2):856-868. ACS Nano. 2025 Aug 19;19(32):29073-29086. ACS Omega. 2025 Apr 22;10(17):17228-17236. Acta Neuropathol Commun. 2024 Sep 14;12(1):150. Acta Neuropathol Commun. 2025 May 27;13(1):118. Acta Pharm Sin B. 2023 Jul;13(7):3027-3042. Adv Healthc Mater. 2021 May;10(10):e2002103. 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Smiles	O=C([C@@H]1CC[C@]([C@H](N)C)([H])CC1)NC2=CC=NC=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Category	Reference compound / Active compounds
Manufacturer - Targets	Apoptosis; Organoid; ROCK
Manufacturer - HS Code	H302, H315, H319, H335
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, protect from light, stored under nitrogen)
Molecular Weight	247342
Product Description	Y-27632 is an orally active, ATP-competitive inhibitor of ROCK-I and ROCK-II, with Kis of 220 and 300 nM, respectively. Y-27632 attenuates Doxorubicin-induced apoptosis of human cardiac stem cells. Y-27632 also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells. Y-27632 primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation[1][2][3][4][5][6][7].
Manufacturer - Research Area	Cancer
Solubility	DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Clinical information	No Development Reported
Isoform	ROCK1; ROCK2
UNSPSC Code	12352005
Precautionary	H302, H315, H319, H335

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