OSW-1

Item no.	HY-101213-500ug
Manufacturer	MedChem Express
CASRN	145075-81-6
Amount	500 ug
Quantity options	10 mg 1 mg 500 ug 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.66
Citations	[1]Burgett AW, et al. Natural products reveal cancer cell dependence onoxysterol-binding proteins.Nat Chem Biol. 2011 Aug 7;7(9):639-47.\|[2]Zhang Y, et al, Effective cytotoxic activity of OSW-1 on colon cancer by inducing apoptosis in vitro and in vivo.Oncol Rep. 2017 Jun;37(6):3509-3519.
Smiles	C[C@@]1([C@@]2(O)[C@H](C)C(CCC(C)C)=O)[C@](C[C@@H]2O[C@@](OC[C@H](O)[C@@H]3O[C@@](OC[C@@H](O)[C@@H]4O)([H])[C@@H]4OC(C5=CC=C(OC)C=C5)=O)([H])[C@@H]3OC(C)=O)([H])[C@@](CC=C6[C@@]7(CC[C@H](O)C6)C)([H])[C@]7([H])CC1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Oxysterol-binding Protein-related Protein (ORP)
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, protect from light, stored under nitrogen)
Molecular Weight	873.03
Product Description	OSW-1, isolated from Ornithogalum caudatum, is a specific antagonist of ooxysterol binding protein (OSBP) and OSBP-related protein 4 (ORP4) with GI50s in the nanomolar range in human cancer lines.
Manufacturer - Research Area	Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Metabolic Enzyme/Protease
Clinical information	No Development Reported

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HY-101213-500ug-safety-datasheet.pdf