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DL-Buthionine-(S,R)-sulfoximine (hydrochloride)

DL-Buthionine-(S,R)-sulfoximine (hydrochloride)

Item no.	HY-106376B-100mg
Manufacturer	MedChem Express
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 25 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.09
Citations	[1]Griffith OW, et al. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem. 1979 Aug 25;254(16):7558-60.\|[2]Vanhoefer U, et al. d,l-buthionine-(S,R)-sulfoximine potentiates in vivo the therapeutic efficacy of doxorubicin against multidrug resistance protein-expressing tumors. Clin Cancer Res. 1996 Dec;2(12):1961-8. Redox Biol. 2025 Feb 25:81:103567.\|Adv Sci (Weinh). 2023 Jun 17;e2206798.\|Algal Res. 2025 Mar.\|Biochem Biophys Res Commun. 2024 Jul 23:733:150436.\|Biochem Genet. 2024 Sep 24.\|Cell Death Dis. 2025 Mar 20;16(1):193.\|Cell Signal. 2025 Jan 3:111583.\|Ecotoxicol Environ Saf. 2022 Dec 1;247:114263.\|Ecotoxicol Environ Saf. 2022, 247: 114263.\|Eur J Med Chem. 2023 Nov 28, 115997.\|FASEB J. 2024 Jul 31;38(14):e23844.\|Free Radic Biol Med. 2024 Jun 19:S0891-5849(24)00531-8.\|J Invest Dermatol. 2024 Dec 24:S0022-202X(24)03027-6.\|Med Oncol. 2023 Apr 10;40(5):141.\|Mol Cell Biochem. 2021 Jan 8.\|Nat Commun. 2024 Aug 30;15(1):7522.\|Nucleic Acids Res. 2020 Sep 18;48(16):9109-9123.\|Res Sq. 2024 Sep 12:rs.3.rs-5065904.\|Research Square Preprint. 2023 May 24.\|Research Square Print. 2023 Mar 24.\|Small. 2021 Nov 1;e2103984.
Smiles	OC(C(N)CCS(CCCC)(=N)=O)=O.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Buthionine sulfoximine (hydrochloride),BSO (hydrochloride)
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Ferroptosis
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	258.77
Product Description	DL-Buthionine-(S, R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent inhibitor of glutamylcysteine synthetase biosynthesis.
Manufacturer - Research Area	Cancer
Solubility	DMSO: < 1 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis
Clinical information	No Development Reported

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HY-106376B-100mg-safety-datasheet.pdf