ONC212

Item no.	HY-111343-100mg
Manufacturer	MedChem Express
CASRN	1807861-48-8
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Metabolism Diabetes Glucose Homeostasis Regulation of Appetite Inhibitors & Compound Libraries Small Molecules By Organ Heart & Blood Cancer Pancreatic Cancer
Type	Inhibitors
Specific against	other
Purity	99.86
Citations	[1]Takenobu Nii, et al. The Novel Imipridone ONC212 Induces Pronounced Anti-Leukemia Effects in Vitro and In Vivo and Is Highly Synergistic with the BCL-2 Inhibitor ABT-199. ASH. 2017.\|[2]Lev A, et al. Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP. Oncotarget. 2017 Sep 12;8(47):81776-81793.\|[3]Wagner J, et al. Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212. Cell Cycle. 2017 Oct 2;16(19):1790-1799.
Smiles	O=C1N(CC2=CC=C(C(F)(F)F)C=C2)C3=NCCN3C4=C1CN(CC5=CC=CC=C5)CC4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	440.46
Product Description	ONC212, a fluorinated-ONC201 analogue, is a promising anti-cancer agent and also a selective agonist of GPR132. ONC212 also induces apoptosis[1].
Manufacturer - Research Area	Cancer; Endocrinology
Solubility	DMSO : 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis
Clinical information	No Development Reported

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HY-111343-100mg-safety-datasheet.pdf