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NUCC-390 (dihydrochloride)

NUCC-390 (dihydrochloride)

Item no.	HY-111793A-25mg
Manufacturer	MedChem Express
CASRN	2749281-71-6
Amount	25 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.19
Citations	[1]Mishra RK, et al. Discovery and characterization of novel small-molecule CXCR4 receptor agonists and antagonists.Sci Rep. 2016 Jul 26;6:30155. Int Immunopharmacol. 2024 Nov 30:144:113707.\|Neurosci Res. 2022 Dec 30;S0168-0102(22)00323-6.\|AAPS Open. 2024 Jan 13:S1687-1979(23)00111-9.\|Proc Natl Acad Sci U S A. 2024 Dec 24;121(52):e2416909121.
Smiles	O=C(N1CCCCC1)C2=NN(CCC)C3=C2CC(NCCC4=CC=NC=C4)CC3.Cl.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	CXCR
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, stored under nitrogen)
Molecular Weight	468.46
Product Description	NUCC-390 dihydrochloride is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 dihydrochloride induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100 (HY-10046)[1]. NUCC-390 dihydrochloride promotes nerve recovery of function after neurodegeneration in vivo[2].
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: 25 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein; Immunology/Inflammation
Isoform	CXCR4
Clinical information	No Development Reported

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HY-111793A-25mg-safety-datasheet.pdf