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Macropa-NH2 (hydrochloride)

Macropa-NH2 (hydrochloride)

Item no.	HY-111895A-1mg
Manufacturer	MedChem Express
CASRN	2443966-86-5
Amount	1 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.51
Citations	J Nucl Med. 2021 Aug 12;jnumed.121.262459. Patent. US20210236667A1. Sci Rep. 2020 Dec 17;10(1):22203. [1]Thiele NA, et al. An Eighteen-Membered Macrocyclic Ligand for Actinium-225 Targeted Alpha Therapy. Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14712-14717.
Smiles	O=C(O)C1=NC(CN2CCOCCOCCN(CC3=NC(C(O)=O)=CC=C3)CCOCCOCC2)=CC(N)=C1.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	ADC Linker; Drug Intermediate; Radionuclide-Drug Conjugates (RDCs)
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	584.06
Product Description	Macropa-NH2 hydrochloride is the precursor of Macropa-NCS. Macropa-NCS is conjugated to Anti-Human HER2 (HY-P9907) as well as to the prostate-specific membrane antigen-targeting compound RPS-070 and is a promising therapeutic radionuclide applied in the treatment of soft-tissue metastases[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO : 83.33 mg/mL (ultrasonic)\|H2O : ≥ 100 mg/mL
Manufacturer - Pathway	Antibody-drug Conjugate/ADC Related; Others
Clinical information	No Development Reported

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HY-111895A-1mg-safety-datasheet.pdf