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3-Hydroxyisobutyric acid

3-Hydroxyisobutyric acid

Item no.	HY-113126-25mg
Manufacturer	MedChem Express
CASRN	2068-83-9
Amount	25 mg
Quantity options	100 mg 10 mM/1 mL 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	93.0
Citations	[1]Podebrad F, et al. Stereodifferentiation of 3-hydroxyisobutyric- and 3-aminoisobutyric acid in human urine by enantioselective multidimensional capillary gas chromatography-mass spectrometry. Clin Chim Acta. 2000 Feb 25;292(1-2):93-105.\|[2]Viegas CM, et al. Evidence that 3-hydroxyisobutyric acid inhibits key enzymes of energy metabolism in cerebral cortex of young rats. Int J Dev Neurosci. 2008 May-Jun;26(3-4):293-9.\|[3]Mardinoglu A, et al. Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes. EBioMedicine. 2018 Jan;27:151-155.\|[4]Landaas S. Accumulation of 3-hydroxyisobutyric acid, 2-methyl-3-hydroxybutyric acid and 3-hydroxyisovaleric acid in ketoacidosis. Clin Chim Acta. 1975 Oct 15;64(2):143-54.
Smiles	O=C(O)C(C)CO
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Targets	ATP Synthase; Endogenous Metabolite
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	104.10
Product Description	3-Hydroxyisobutyric acid is an intermediate in the metabolic pathways of L-valine and thymine, and can be found in urine. 3-Hydroxyisobutyric acid is a secreted mediator of endothelial cell fatty acid transport and insulin resistance. 3-Hydroxyisobutyric acid can also inhibit key enzymes of energy metabolism in the cerebral cortex of young rats. The levels of 3-Hydroxyisobutyric acid are closely related to various diseases such as 3-hydroxyisobutyric aciduria, diabetes, and ketoacidosis[1][2][3][4].
Manufacturer - Research Area	Metabolic Disease; Neurological Disease
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Isoform	Human Endogenous Metabolite
Clinical information	No Development Reported

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HY-113126-25mg-safety-datasheet.pdf