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MnTBAP (chloride)

MnTBAP (chloride)

Item no.	HY-126397-10mM
Manufacturer	MedChem Express
CASRN	55266-18-7
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Citations	[1]Jing Yu, et al. MnTBAP Therapy Attenuates Renal Fibrosis in Mice With 5/6 Nephrectomy. Oxid Med Cell Longev. 2016;2016:7496930.\|[2]Qian Zhou, et al. MnTBAP Increases BMPR-II Expression in Endothelial Cells and Attenuates Vascular Inflammation. Vascul Pharmacol. 2016 Sep;84:67-73.
Smiles	[Cl-][Mn+3]12([N](C(C=C3)=C4C(C=C5)=CC=C5C(O)=O)=C3C(C(C=C6)=CC=C6C(O)=O)=C7C=C8)[N-]7C8=C(C(C=C9)=CC=C9C(O)=O)C%10=[N]1C(C=C%10)=C(C(C=C%11)=CC=C%11C(O)=O)C%12=CC=C4[N-]2%12
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	NF-κB
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, sealed storage, away from moisture)
Molecular Weight	879.15
Product Description	MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research[1][2].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	0.5 M NaOH: ≥ 20 mg/mL\|1 M NaOH: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	NF-κB
Isoform	NF-κB
Clinical information	No Development Reported

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HY-126397-10mM-safety-datasheet.pdf