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IRAK inhibitor 4

IRAK inhibitor 4

Item no.	HY-13278-1mg
Manufacturer	MedChem Express
CASRN	1012104-68-5
Amount	1 mg
Quantity options	10 mMx1 mL 1 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis By Cell Type Hematology Leukemia Lymphoma Inhibitors & Compound Libraries Small Molecules By Organ Heart & Blood Cancer Neurodegeneration Markers
Type	Inhibitors
Specific against	other
Purity	99.77
Citations	[1]Marinho FV, et al. Lack of IL-1 Receptor-Associated Kinase-4 Leads to Defective Th1 Cell Responses and Renders Mice Susceptible to Mycobacterial Infection. J Immunol. 2016 Sep 1;197(5):1852-63.\|[2]Talreja J, et al. Dual Inhibition of Rip2 and IRAK1/4 Regulates IL-1β and IL-6 in Sarcoidosis Alveolar Macrophages and Peripheral Blood Mononuclear Cells. J Immunol. 2016 Aug 15;197(4):1368-78.\|[3]Li Z, et al. Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies. J Clin Invest. 2015 Mar 2;125(3):1081-97.
Smiles	OC1CCC(N2C3=C(C=C(C=C3)C(NCCC(C)C)=O)N=C2NC4=NNC5=C4C=C(C=C5)C6=CC=CC=C6OC(F)(F)F)CC1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	IRAK
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	620.66
Product Description	IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4(IRAK4) inhibitor.
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO: 12.5 mg/mL (ultrasonic)
Manufacturer - Pathway	Immunology/Inflammation
Isoform	IRAK4
Clinical information	No Development Reported

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HY-13278-1mg-safety-datasheet.pdf